Good morning dispensers of wisdom!

Is your afternoon LaCroix a wellness hack or just expensive bubbles? A new study in BMJ Nutrition suggests the CO2 in sparkling water can nudge your metabolism by making blood more alkaline, helping red blood cells scoop up glucose faster. It sounds like a breakthrough until you look at the math: to lose real weight via fizz, you would essentially need to be hooked up to a dialysis machine of Perrier. While the metabolic boost is a cool bit of biochemistry, the effect is likely too small for a scale to notice and might just leave your more bloated than boosted.

Today’s issue takes 5 minutes to read. Only got 1? Here’s what to know:

  • Common IBS meds are linked to new long-term safety concerns

  • 80% of Canadian sepsis patients face life-saving antibiotic delays

  • Early ADHD diagnosis leads to better grades and higher graduation rates

  • Canada approved neffy, the first needle-free epinephrine nasal spray

  • Scientists finally found a way to block the Epstein-Barr virus

  • Federal gas tax pause shaves ten cents off regular fuel

Let’s get into it.

Staying #Up2Date 🚨

1: Supporting Students With ADHD Starts Early

A cohort study of 580K individuals found that an earlier age at ADHD diagnosis is associated with better GPA at age 16 years, as well as a higher probability of completing an academic upper secondary degree. Additionally, those who received a diagnosis later on (closer to age 16) were at a higher risk of school dropout. These results support early screening for ADHD in primary and secondary school, as well as establishing robust support for those who receive a late diagnosis in order to improve educational outcomes for all children with ADHD.  

2: Sepsis: The 60-Minute Miss

A Canadian study published in the CJHP looked at how quickly antibiotics are administered to sepsis patients in Canadian EDs. After reviewing over 1,200 doses, researchers found that nearly 80% of patients faced at least one significant delay, and almost half missed the 1-hour window for their very 1st dose. The authors noted that these lags are often tied to systemic bottlenecks and could be putting patients at higher risk, signalling a major need for new hospital-wide protocols to speed up administration.

3: Long-Term Risks for Common IBS Meds?

A 20-year study of 650K patients is raising questions about long-term IBS treatments, specifically antidepressants used for gut-brain signalling and antidiarrhoeals like loperamide. Researchers found that long-term antidepressant use was associated with a 35% increase in the risk of death, while loperamide and diphenoxylate were linked to nearly twice the risk. Though the individual risk remains low and doesn't prove direct causation, the authors suggest we must more carefully weigh the safety of these medications for chronic symptom management.

Shelf Watch 🏥

Drug Shortages ⚠️

  • Phenytoin (capsules/chewable tablets): Supply remains tight for both sodium capsules and chewable formats used in seizure control. Announcement: April 1, 2026.

    Estimated End Date: May 8, 2026 (~3 weeks remaining).

Newly Approved Drugs

  • neffy (epinephrine nasal spray): Approved April 15, 2026. This is the 1st needle-free epinephrine treatment for severe allergic reactions in Canada for adults and children. Expect it to be available in pharmacies by summer 2026. Expect it to be available in pharmacies by summer 2026.

  • DENOZA (denosumab injection): Approved April 7, 2026. It’s authorized for the treatment of osteoporosis in postmenopausal women and men at high risk for fracture.

The Robot in the Dispensary 🤖

The "human" pharmacist is at a crossroads as tech leaps ahead

What happened: TELUS Health recently dropped its 2026 Pharmacy Trends Report, and it revealed a pretty wild paradox. While nearly half of Canadian pharmacists (47%) say AI is the biggest thing to hit the profession since the invention of the pill counter, only 3% are actually using it in their day-to-day.

Why it matters: With 5.9 million Canadians without a family doctor, the pharmacy is fast becoming the hub of the patient journey, filling the primary care gap one assessment at a time. In Ontario alone, the list of minor ailments pharmacists can assess just expanded again to include 14 new conditions like shingles and acute pharyngitis.

As the clinical to-do list gets longer, the pressure on pharmacy teams is mounting. Recent surveys show that nearly 80% of Canadian pharmacy professionals are at risk of burnout, citing the heavy admin load as a major culprit. The TELUS report suggests a way out: AI could automate up to 70% of the repetitive stuff, like billing paperwork and drug interaction screens, potentially saving hours of time every week.

But: If the tech is so great, why aren't we all using it? Turns out, 62% of pharmacists are hesitant because of "unreliable outputs" (nobody wants a hallucinating robot dispensing meds) and 45% are just fed up with software that doesn't talk to each other. We’re also seeing that generic AI just doesn't cut it, purpose-built pharmacy AI is twice as effective as the basic stuff. Until these systems can talk to hospital records and clinic notes seamlessly, the human pharmacist is still the only real gatekeeper for patient safety.

Bottom line: AI isn't replacing the pharmacist, but it is surfacing as a potential tool to manage the growing admin load. This balance is especially critical as we approach Oct. 1, when new federal rules will allow pharmacists to therapeutically substitute controlled substances, a move that increases both the clinical impact and the regulatory responsibility of the profession.

Hot Off The Press 🗞️

1: 🧬 Scientists may have finally cracked the code on stopping the Epstein-Barr virus (EBV), which currently hitches a ride in about 95% of the human population. In a recent study published Cell Reports Medicine, researchers used "humanized" mice to develop monoclonal antibodies that block the virus from breaking into our immune cells. One specific antibody was a total lockout, completely preventing infection in lab models. Since EBV is linked to everything from mono to certain cancers and multiple sclerosis, this is a massive step toward a preventive therapy.

2: 📵 The federal government recently that it’s "very seriously" considering a national social media ban for children under 16. The move follows a non-binding resolution passed at the Liberal party policy convention in Montreal, aimed at curbing online harms and addressing the youth mental health crisis. The feds are also weighing whether the legislation should extend to AI chatbots, as concerns grow over how "helpful" those digital friends really are.

3: 🏒 The NHL post-season schedule was released on April 16, with 3 Canadian teams officially in the hunt for the Stanley Cup. The Ottawa Senators will kick things off this Saturday against the Carolina Hurricanes, followed by the Montreal Canadiens taking on the Tampa Bay Lightning on Sunday. The Edmonton Oilers are also set to begin their run early next week, as the league prepares for a champion to be crowned by late June.

4: ⛽ Prime Minister Mark Carney recently announced that the feds are officially hitting the pause button on the federal gas tax starting April 20. The move should shave about 10 cents per litre off regular gas and 4 cents off diesel until at least Sept. 7, just in time for that late-summer road trip. The relief comes as Middle East tensions have sent prices at the pump skyrocketing, though the opposition is already calling the cut "too little, too late."

RXBriefly Picks 💊

🎓 Learn: how to navigate the shifting GLP-1 landscape. Join Dr. Sean Wharton on April 30th for a deep dive into the latest clinical data. This webinar moves beyond the scale to explore systemic, multi-organ benefits and a blueprint for total metabolic health.

🍳 Make: this garlic-butter shrimp scampi. Tossed with lemon, white wine, and fresh parsley, this elegant 15-minute pasta is the perfect emergency weeknight dinner for when you're short on time but still want a quality meal.

🤑 Save: on BBQs and patio furniture at RONA this week. With spring teasing a permanent stay, it’s the perfect time to snag early-season deals on grills and outdoor sets before the summer rush begins.

📖 Read: generational wealth wisdom. A refreshingly blunt look at why the old-school rules of patience and spending less than you earn are still the only reliable ways to survive a high-debt, high-inflation medical career.

🌍 Travel: to this this remote cloud forest retreat in Costa Rica. With 180-degree views, wood-fired hot tubs, and absolute seclusion, it’s the ultimate spot for trading digital noise for high-altitude serenity.

Relax 🧩

First clue:

PHARMACY CROSSWORD HERE

Need a rematch? We’ve got you covered. Check out our Crossword Archive to find every puzzle we’ve ever made, all in one place.

Think you crushed it? Challenge your pharmacist friends to beat your time.

Meme Of The Week

Help Us Get Better

That’s all for this issue.

Cheers,

The RxBriefly team.

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